The UK’s engagement with the Indo-Pacific region entered a new phase in the post-Brexit era. The Johnson Government put forward an Indo-Pacific policy framework for the first time in the Integrated Review which was issued in March 2021. This framework，and the UK’s actual activities demonstrate the UK’s commitment to strengthening its economic，trade and scientific and technological ties with players in the Indo-Pacific region，as well as its intention to gradually increase its naval deployment and regular maritime presence in this region. The need to address the economic challenges of Brexit and the perception of its prosperity as inseparable from Indo-Pacific security and stability are the key factors driving the UK’s intensification of Indo-Pacific activities，in the context of its increasingly negative view of China’s rising international influence or the so-called “international assertiveness”. In ensuring the security of Euro-Atlantic region，which is more important to the UK，strengthening the security commitments to NATO’s European allies after Brexit，and restricting limited resources，the UK’s Indo-Pacific “tilt” has obvious limits in areas of defence and security. Economic and trade issues will take a higher priority.