During the “14^th Five-Year Plan” period，our country will further promote the Guangdong-Hong Kong-Macao Greater Bay Area to build an international science and technology innovation center，continue to strengthen regional collaborative innovation，continue to deepen Guangdong，Hong Kong and Macao science and technology innovation exchanges and cooperation，work together to build a regional collaborative innovation community，and strive to create a source of scientific and technological innovation，and the highland of technology industry. However，the Guangdong-Hong Kong-Macao Greater Bay Area still has some difficulties in strengthening regional collaborative innovation and building an international science and technology innovation center. For example，the positioning of various regions in the Guangdong-Hong Kong-Macao Bay Area overlaps，which is not conducive to the coordinated development of innovation policies；System and policy boundaries are clear，and there are obstacles to the circulation of elements；Moreover，investment in technological innovation in the Guangdong-Hong Kong-Macao Bay Area is facing fierce international competi-tion. In response to the above difficulties，this report points out that the Guangdong-Hong Kong-Macao Greater Bay Area to build an international science and technology innovation center can be overcome by a series of measures such as the establishment of the Guangdong-Hong Kong-Macao Bay Area Science and Technology Innovation Committee；the development of Guangdong-Hong Kong-Macao Bay Area stations；and the formation of a government-market symbiosis and innovation relationship.