China’s strategic conception of “One Belt and One Road” and approval of the establishment of China （Guangdong） Free Trade Zone，endow Guangzhou Port a new opportunity for strategic transformation and intension. Around the purpose of building a world shipping center in Guangzhou，this paper proposes the strategic position and mission objectives of building Guangzhou Free Trade Port innovatively，formulates plans corresponding to “three phase” strategic path and use free trade port as the carrier to make breakthrough in seven key aspects，such as policy environment，culture brand，infrastructure，core business expansion，intelligent Nansha，related industries development and economic radiation，so as to stimulate the revival of Guangzhou Millennium business and the sustainable development of urban new economy. <<