The PRD is one of the three mage-urban regions in China. s starting from 1989，the PRD has totally produced four regional urban development plans. In these four versions of regional plan，the 1994 version of plan and the 2008 version of plan had played more significant roles. In Pearl River Delta，the first development plan with the concept of “new town center” was the Futian Town Center development plan of Shenzhen. The development of CBD in cities has played a key role in promoting urban service sector development in Pearl River Delta. What we can learn from PRD in CBD development including：The position of a city in the global manufacture chain determines how strong the force the city can generate in its CBD development；in mega-cities region，the regional development trends have a significant impact on a city’s CBD development；principles are differences between the Central Activity Zone and the Central Business District development. The “21th Century new sea silk road” strategy is an opportunity for urban service sector development in PRD；it is a great opportunity for the CBD development in the city as well. In this new era，the coordination between the CBDs functional development is crucial in the region，the CBDs in the PRD should be functional diversification，and the land mixed use. <<