Since the 21st century, a new round of technological revolution and industrial revolution gave birth to the rise, the world's major countries are scrambling to find breakthrough for the development of science and technology innovation, grab the future development opportunities.In the fierce competition, only innovators, innovators is strong, only innovators.Advanced developed areas in eastern Yangtze river delta economic zone in China, in the new era is more need to pay attention to improve the ability of original innovation and integrated innovation, fully accelerate the development of regional innovation fusion, to cultivate internationally competitive industrial clusters and regional economy.The countermeasures of development of Yangtze river delta regional innovation fusion approach is, first of all, to play in the development of Shanghai in the Yangtze river delta innovation fusion engine, promote Yangtze river delta regional independent innovation ability;Second, to further improve the Yangtze river delta regional industry technology innovation alliance, to speed up the Yangtze river delta regional scientific and technological innovation in the field opening to the outside world, further guide the linkage development of national high-tech zone. <<