"One Belt And One Road" is a national strategy proposed and implemented by China, which brings new opportunities for complementarity and open development in the areas along the belt and road. Guizhou province combines its own development situation with the integration of advantageous resources to actively participate. Use in guizhou "near edge, offshore and jiang" location, in the national "five longitudinal and five horizontal" integrated transport channel in baotou to guangzhou and Shanghai to ruili transport channel crossed and advantages, seize the "area" strategy to guizhou the opportunity of introducing talents, regional division of labor, etc, fruits have been achieved. All the way how to "area" strategy as an opportunity to promote the system innovation, adjust the industrial structure, attract talent and technology, to achieve the long-term goal of sustainable development, is to explore the content of this article.