As a key node on the “21st-Century Maritime Silk Road”，Singapore has paid positive attention and participated in the construction of “The Belt and Road” Initiative，and new progresses have been made in the aspects of major projects cooperation，financial cooperation，trade cooperation and cultural exchanges. Meanwhile however，the current Sino-Singapore cooperation is faced with some challenges，such as geopolitical factors，investment risk as well as the lack of cultural exchanges. In order to cope with these problems and improve the level of interconnection between China and Singapore，China can make efforts to enhance economic and trade cooperation，improve the ability of enterprises to invest，abroad and strengthen cultural exchanges.