Since its proposal by China’s leaders in 2013，the “Belt and Road” Initiative has been attracting a lot of attention at home and abroad in terms of politics，economy，trade and market. As the implementation of the “Belt and Road” Initiative offers quality services to countries along the “Belt and Road”，and creates new opportunities for overseas development of domestic and foreign enterprises，domestic enterprises should seize the opportunity，closely follow the national preferential policy under the “Belt and Road” Initiative and choose to jointly develop overseas markets，thus bringing China’s products，services and brands，and even influence，into more countries along the “Belt and Road”. This paper，based on the analysis of trade in medical devices in countries along the “Belt and Road” in 2017，holds that to make greater and steady progress，enterprises should，while going global，integrate again overseas advanced technologies，brands，high-end talents，resources，market channels，and advanced management experience and seek the room for increase in share of medical device markets in related countries along the “Belt and Road”.