Since the deepening of medical reform，the top-level design of the national drug policy system has been further improved，the national essential drug system has been further consolidated，the drug price management system in line with the characteristics of China’s drug market has been gradually established，the reform of drug supply has been gradually deepened，the reform of drug circulation system has achieved remarkable results，and the centralized drug procurement system has been established In addition，the negotiation mechanism of national medical insurance drug catalog access price was gradually established，and the comprehensive clinical evaluation mechanism of drugs was gradually established. To improve the reform of drug supply guarantee system in China，we should turn to high-quality development，focus on quality and rational use，and strengthen multi-party participation and collaborative governance. Based on the national essential drug system，we should strengthen the reform coordination of the drug supply guarantee system，continuously guarantee the drug accessibility，improve the quality of domestic generic drugs，and promote the rational use of drugs as the main contents，so as to establish a stable and sustainable drug supply guarantee system.