The crisis in Ukraine in 2014 is the result of the superposition of Ukraine’s domestic problems and the geopolitical game of major powers. It is also one of the most symbolic events in the competition between the United States，Europe and Russia for dominance in Eurasia after the cold war. The unexpected COVID-19 swept the world in 2020-2021 years，but the conflict in the area of Donbass region has been warming up. Ukraine’s investment attraction has decreased，business enthusiasm has decreased，and domestic political reform is not good. The reasons for the unresolved crisis in Ukraine are complex. In the past year，the United States and Europe have still imposed sanctions on Russia，and the security game between the United States and Russia in the Black Sea region continues. The different positions of the United States and some EU countries on “Nord Stream 2” have strengthened the complexity of the situation. The United States regards China as its main competitor，which has become an important factor affecting China Ukraine economic and trade cooperation. Whether the Ukrainian crisis can be resolved depends on whether the countries concerned have the demand，sincerity and ability to establish effective multilateral mechanisms. In the future，Ukraine is still the anti-Russian fulcrum that the United States will not give up，a buffer zone that Europe is striving for，and a sensitive area that Russia is trying its best to lock up.