The integration of industry and education is the basic requirement of talent training in the new era. Under the background of the integration of industry and education，the collaborative innovation of political and industrial research is the effective integration of various resources by scientific research institutions，enterprises，universities and the government. Under the background of the integration of industry and education，the efficiency and effectiveness of scientific research institutions，governments，universities and enterprises are still unsatisfactory. To accelerate the construction of local collaborative innovation mechanism，several key points are as follows：First，we need to formulate collaborative innovation target planning and build local innovation and development ecology；Second，we need to establish an incentive mechanism for interest distribution to generate lasting impetus for collaborative innovation；Third，we need to foster a culture of win-win cooperation and innovation，and create an atmosphere of equal participation and interaction；Fourth，we need to avoid formalism and promote the commercialization and application of scientific and technological achievements. Through continuous reform and construction，the local collaborative innovation mechanism will become an important starting point to promote the development of mass entrepreneurship and innovation in a deeper direction.