From the perspective of “social demand catalyzes changes in strategy，technological advancement expands communication effectiveness”，this article analyzes the popular science communication strategies of new media communication networks，and quantitatively model and analyze some research objects. It is pointed out that science popularization based on new media communication network can be used in the three directions of incentive mechanism，Matthew effect avoidance and official account alliance，actively introduce Internet thinking，actively guide the whole process of science popularization，and do a good job in the construction of supporting science popularization service platform. The comprehensive informatization and internetization of popular science communication work has become a basic development trend.