In 2016，General Secretary Xi Jinping’s important speech on “Science and Technology Innovation and Popularization of Science Are the Two Wings of Realizing Innovation and Development” brought new spring to the popularization of science. At this important historical stage，clarify the true meaning of popularization of science and find the misunderstandings of past science popularization work. It is of great significance to promote the in-depth development of popular science. Based on the typical cases of the Chinese Academy of Sciences in the cultivation of high-end popular science brands，this article analyzes the rules and models of building high-end popular science brands，and provides references and references for the development of high-end popular science brands in my country in the future.