The integrated development of the Yangtze River Delta is a national strategy. The region is a vanguard for moving forward the “Belt and Road Initiative” and the development of the Yangtze River Economic Belt. The Delta occupies a frontier position in China’s opening-up landscape. It should to seize the major opportunities for integrated high-quality development in the Yangtze River Delta，give play to its comparative advantages in terms of strategic location，transportation hubs，hi-tech industries，and distinctive. The region should strive to properly handle key issues such as planning and layout，resource integration，identification of priorities. It is important to build distinctive brands in terms of lean manufacturing，regional culture，transportation connectivity and top-notch industrial parks.