This report will study the changes of three major international innovation and entrepreneurship indexes in recent years and the characteristics of international indexes，and explore the development stage，opportunities and challenges of China’s innovation and Entrepreneurship from an international perspective. This report studies the structure and connotation of three international indexes：The Global Innovation Index，the Global Entrepreneurship Monitor Index and the Global Entrepreneurship Ecology Index，and shows the characteristics of international indexes by comparing with domestic indexes. The study found that despite the impact of COVID-19，China’s double creation resources continue to be actively invested，and China’s dual ecological environment and innovative output remain a good and stable development trend.