The recommendations of the 14th Five-Year Plan and the 2035-year long-term goal put forward “building a highland of scientific research and innovation that gathers outstanding talents at home and abroad”. In the new stage of development，the agglomeration of creative talents is one of the key issues for achieving high-quality development in our cities. The agglomeration of creative talents not only depends on the level of urban economic development，but also on the city’s cultural consumption and cultural heritage. In this regard，based on the theoretical framework of Cultural Amenity（CA），this article compares the agglomeration patterns of creative talents in Beijing and Shanghai and the development trend of cultural amenities，and clarifies the role of cultural amenities in the agglomeration of creative talents in the central cities of the two countries. The empirical results based on panel data show that，compared to the relationship between the process of agglomeration of creative talents in Shanghai and cultural amenities，the process of agglomeration of creative talents in Beijing is more attracted by the local cultural comfort system. However，the interior of Beijing’s cultural amenities. The structure needs to be improved and the quality needs to be further optimized. This report hopes to make better use of the synergy power of “cultural comfort-creative talents”，further stimulate the innovative and creative momentum brought by the scientific and orderly gathering of talents，and accelerate the construction of world-class innovative and creative highlands in Beijing and Shanghai.