In the era of big data，data is well recognized as a new factor of production for digital economy. New data infrastructure is demanded to safely and efficiently mining the value of massive private data across multiple domains，by combining the “ABCD” capabilities from artificial intelligence，blockchain，cloud computing and big data technology. Blockchain-based privacy-preserving computing technology is further emerged to comply with new data protection regulation and enable privacy-preserving data fusion for collaborative business. In this report，we share our experience on exploring and applying blockchain-based privacy-preserving computing technology，by introducing the history of privacy-preserving computing，key supporting technology，the practice of multi-party big data privacy-preserving computation at WeBank，and typical use cases in finance，e-government，and healthcare sectors. As more strict international and domestic data protection regulations come into effect，privacy-preserving computing will play a key role in data-driven industry. By offering full life cycle protection on data usage，privacy-preserving computing can achieve secure storage，trust transfer，and collaborative production，to establish a revolutionary digital infrastructure for more sustainable and rapid digital economy development.