This report presents the overall situation and regional differences of the development of China’s cultural industry from the perspective of multi-source big data. The comprehensive index of cultural industry covers 4 second-level indicators，8 third-level indicators and 23 fourth-level indicators. The construction of cultural industry in Beijing and Shanghai has achieved remarkable results. Wuhan has significantly improved its cultural communication index and become a new star in the development of cultural industry. From the perspective of sub-indexes，the weight of cultural communication index is 0.6277，cultural resources index is 0.2040，cultural industry index is 0.0524，and cultural development potential index is 0.1159. It can be seen that the influence of cultural communication varies greatly among different regions，followed by the richness of cultural resources，the potential of cultural development and the benefits of cultural industry. From the perspective of regional differences，the development of China’s cultural industry in the east is far ahead of that in the west，with unbalanced and insufficient regional development.