In order to balance the rights and obligations between the copyright owner and the information location service provider，we urgently need to clarify the application conditions and application disputes of the safe harbor rules in the process of determining the responsibility of copyright infringement. This article believes that direct infringement by a third party other than the information location service provider is the prerequisite for the application of this rule，and the fact that the information location service provider has no subjective fault is the substantive condition for its application. At present，whether all types of links are applicable to the “notification-delete” rule，what is the time standard for the information location service provider to “timely” take necessary measures after receiving the copyright owner’s notification，and whether the copyright owner’s unqualified notification can prove the subjective faults of information location service providers are the main controversial issues faced by the safe harbor rules in judicial practice.