Per capita GDP is not only an important indicator to measure the degree of economic development of a region，but also one of the important indicators to reflect the level of modernization. In 2019，the per capita GDP of 36 countries and regions in the world exceeded US $25000. There are 6 prefectures and cities，23 counties and urban areas in China，and the per capita GDP exceeds US $25000. If the per capita GDP exceeds US $25000，significant changes will take place in the urban industrial structure，production mode and residents’ lifestyle. The analysis of small and medium-sized cities with per capita GDP exceeding US $25000 has a positive reference value for the city to determine the future development strategy and direction.