The increasing coverage of AIDS prevention has brought the study of AIDS to the academic field of health communication. The stigma against people living with HIV stems from fear of the disease itself，and the fear is caused by a lack of understanding. Therefore，the media should shoulder more social responsibilities when constructing public issues related to AIDS，and actively play the agenda-setting function to create a pseudo-environment conducive to AIDS prevention and eliminate stigma for the audience. Attribution is the main psychological process in which individuals choose certain behaviors for cognitive objects. It is of great significance for the media to positively figure out the attributional psychology of the audience when they receive information to effectively set the agenda of AIDS prevention reports. The purpose of this study is to solve the question “Where do the stigmatized perceptions of the audience start and how to resolve it？” This study analyzes several domestic influential traditional media’s AIDS-correlated reports on Sina Weibo as samples，probe into the relations between attribution and the stigmatized perceptions of audience when constructing the framework of AIDS-correlated reports，so as to find better ways for media to guide and rectify the audience.