This study takes 20 typical professional microblog opinion leaders in different fields as the observation objects，makes a quantitative statistical analysis of 2808 microblog contents，and investigates the social responsibility performance of professional microblog opinion leaders. The study found that there is still room for improvement in the social responsibility performance of professional microblog opinion leaders. The average social responsibility score of the selected professional microblog opinion leaders is 2.4972（the average score rate is 49.95%），which is less than half of the total score. Among them，professional microblog opinion leaders scored well in “information production A1”，but there is still room for improvement in the performance of social responsibility in “value guidance A2”，“cultural education A3” and “coordination communication A4”.