To play the leading role of Shandong peninsula city group in the Yellow River basin，the key is to practice internal skills，and to highlight the core position of scientific and technological innovation in building the “Yellow River leading”. Around the Yellow River basin ecological protection and high quality development strategy needs，around the shandong economic and social development needs，strengthen the basic research，focus on original innovation，and fully draw lessons from Shanghai，Jiangsu，Zhejiang and other places also make science and technology innovation experience，comprehensively enhance the shandong’s capacity for independent innovation，improve the scientific and technological innovation system，to be the pioneer of science and technology innovation in the Yellow River valley bravely.