Accelerating the construction of intellectual property diversified dispute resolution mechanism in the Guangdong-Hong Kong-Macao Greater Bay Area（GBA）is the inevitable requirement and essence of regional innovation optimization. Under the background “one country，two systems and three jurisdictions”，the judicial dispute resolution mechanism of GBA face the difficulties in application and limitation of role. Diversified dispute resolution mechanism could rationalize the allocation of dispute resolution resources and improve the dispute resolution system，which can relieve the pressure of increasingly complicated intellectual property disputes in the GBA. It is suggested that setting up the GBA intellectual property dispute resolution center and platform based on it，to improve the various alternative dispute resolution mechanisms and form an efficient diversified intellectual property dispute resolution mechanism.