This paper focuses on the key points，highlight the key points，combine macro and micro，international and domestic，personal observation and authoritative analysis. Through analysis and research，the author believes that in the future，the world will face profound changes in science and technology industry，economic and trade pattern，and power balance. China will enter a new stage of development and build a new pattern of development. Shenzhen is faced with major opportunities such as “dual zone drive” and comprehensive reform pilot，and has to face the challenges of supply chain security threats，resource constraints tightening and regional competition intensifying. It is suggested to strengthen the innovation ability，improve the quality of supply，optimize the allocation of resources，expand the two markets，and strengthen the logistics guarantee. We should make great efforts to make up for the weaknesses，strengthen the weak points and plug up the loopholes，and strive to build the highland of global innovation，the center of intelligent manufacturing，the hub of modern logistics，the fulcrum of double circulation and the gathering place of high-quality resources.