Since the collapse of the Soviet Union，the five Central Asian countries have joined various types of international and regional organizations for protecting their independency，sovereignty and economic development. These international and regional organizations have played an active role in promoting stability and economic development in Central Asia. During the COVID-19 epidemic，international organizations and Central Asian countries have carried out effective anti-epidemic cooperation，which has played an important role in the Central Asian countries to combat the epidemic and stabilize the economic and social order. This not only reflects the strong influence of international organizations in Central Asia，but also shows that under the new situation，the external forces behind international organizations further win over Central Asian countries through anti-epidemic assistance to enhance their own influence.