Guangzhou has a solid foundation for building an international exchange center. In the 14th Five-Year Plan period，Guangzhou will face favorable opportunities such as the continuous expansion of China’s opening-up，new initiatives in major country diplomacy with Chinese characteristics，high-quality joint construction of the Belt and Road Initiative and accelerated construction of the Guangdong-Hong Kong-Macao Greater Bay Area. Guangzhou should take measures to optimize the working mechanism，participate in the international platform，expand the friendship city network，promote its influence in holding international events，spread international city image，and strengthen the role of overseas Chinese，so as to serve the building of the new development paradigm by building a higher level of international exchange center，and make greater contributions to shaping a more favorable external environment in the 14th Five-year period.