Based on the investigation materials，mainly inclueds the investigation of the pharmaceutical retail chain enterprises in Shanghai and Beijing，the interviewing of the two cities’ community healt service centers，using the relevant figures released by the bureau of health，we analyze the feasibility of pharmaceutical separation. Through the investigation，interview and data analysis we get the conclusion as follows：for Beijing，Shanghai and other economically developed regions，they can implement pharmaceutical separation，the medical institutions and some secondary hospital outpatient pharmacy business can tranfer to the social pharmacy. This is good for all parties，including patients and medical institutions and doctors.