“Two-Invoice System” is conducive to compress the space of drug distribution，regulate the distribution order，and improve the market concentration of distribution industry，however，it also results in the marketing model transformation of pharmaceutical industrial enterprises and distribution enterprises，kickback decrease and cost increase of medical institutions. Under the impact of “Two-Invoice System” and other health care policies，it is likely for hospitals to choose the mode of pharmacy trusteeship，while the pharmaceutical enterprises，especially the distribution enterprises should take the opportunity to make business model innovation and transform to be the pharmaceutical comprehensive service providers.