As the world today is marked by major changes that’s rarely unseen in a century，the construction of Hainan Free Trade Port Plan has marked the beginning of full implementation of the opening up strategy in the new era. As a strategic location connecting Hainan and the hinterland economy，Guangdong will develop in cooperation with complementary advantages. Building upon the research on the construction of Hainan Free Trade Port and the status quo of Guangdong’s opening to the outside world，this report analyzes the impact of Hainan Free Trade Port construction on Guangdong’s development. It finds that against the background of Hainan Free Trade Port，the opportunities and challenges of Guangdong’s opening-up coexist. On the one hand，Guangdong can seize the major opportunities in the construction of Hainan’s Free Trade Port，utilize strong reform forces to promote the formation of a high-quality and open economic structure，make use of the Hainan-Guangdong linkage effect to increase the level of all-round opening up，and accelerate the formation of complementary advantages with Hainan so to inject new impetus into the expansion of opening up.On the other hand，Guangdong is still faced with the three challenges of intensified regional competition brought about by the construction of the Hainan Free Trade Port，the risk of diversion of high-end resources and factors，and Hainan’s implementation of catching up with the support of digital economy development and intensifying competition in the development of emerging industries.Therefore，it is of essence that Guangdong adopt the following policy suggestions so as to strive to be in the forefront of the country in further opening up to the outside world，and support the construction of a new development pattern. It includes that actively innovating and constructing a coordination and cooperation mechanism between Guangdong and Hainan，giving full play to the advantages of the “dual zone” strategy to enhance the competitiveness of opening up，leading the optimization and upgrading of the layout of emerging industries，and creating a new era of opening up and innovation. It is in the forefront of the country in further opening up to the outside world，and is responsible for Guangdong to support the construction of a new development pattern.