Under the new development pattern with domestic circulation as the main body and domestic and international dual circulation promoting each other，the commerce and circulation industry plays an increasingly important role in the whole economic society. At present，the rapid development of digital technology makes the original business circulation system difficult to adapt to the needs of economic development. Digital transformation will be the core issue of the future business circulation enterprises. Based on the context and the analysis of the application of digital technology in commerce and circulation industry，combined with the problems existing in the digital transformation in Guangdong-Hong Kong-Macao Greater Bay Area，this paper analyzes the new opportunities of digital transformation，and puts forward the countermeasures and suggestions of commerce and circulation industry on the digital transformation in Guangdong-Hong Kong-Macao Greater Bay Area.