The establishment of Zhanjiang as the Guangdong Provincial Sub-center is a major decision made by the Guangdong Provincial Party Committee to implement the regional coordinated development strategy and a goal to be basically achieved during the 14th Five-Year Plan. Whether this goal can be achieved as scheduled is of great concern. This article starts from explaining the significance of Zhanjiang’s construction of the provincial sub-center，objectively analyzes the main advantages and main shortcomings of Zhanjiang’s construction of the provincial sub-center，combines the implementation of the Guangdong-Hong Kong-Macao Greater Bay Area strategy background，and proposes the ideas and countermeasures for seizing the oppoturnity and for accelerating the construction of provincial sub-centers.