This report used the undesirable super-efficiency SBM model to measure the cultivated land use efficiency of 11 municipal units in the Pearl River-Xijiang River Economic Belt from 2006 to 2018，and the Malmquist-Luenberger Productivity Index to describe the dynamic characteristics of Total Factors Productivity of cultivated land use in the Pearl River-Xijiang River Economic Belt；and utilized Tobit regression model to explore the main influence factors of cultivated land use efficiency in the Pearl River-Xijiang River Economic Belt. The conclusions are as follows：from 2006 to 2018，the overall cultivated land use efficiency of the Pearl River-Xijiang River Economic Belt shows a fluctuating upward trend，but the overall efficiency is not high；the Total Factor Productivity of cultivated land use efficiency in the study area shows a downward trend，which is mainly constrained by the restraint of technological progress；the level of economic development and the level of related technologies are important factors affecting the cultivated land use efficiency in the Pearl River-Xijiang River Economic Belt，while the endowment of cultivated land resources plays a negative role，and the influence of government policies is insignificant. This report puts forward suggestions from three aspects：to formulate differentiated agricultural land policy，to accelerate the construction of agricultural development science and technology support system，and to strengthen agricultural infrastructure construction.