Chip is not only the foundation of modern ICT industry，but also one nation’s “industrial grain” and the commanding height of international competition. Although China is the world’s largest chip market，Chinese suffers from “low-end locking” in the global value chain due to the long-term lack of domestic chip innovation capability. How to build a strong “Chinese Core” is vital for dealing with the “bottleneck” challenge，improving the Chinese firms’ competitivenessand buildingthe global innovation powerhouse. As chip industry is a globalized industry，under the new wave of technological revolution，the organization and industry boundaries are blurred，and the competition is more and more eco-based. It is hard to achieve chip industry indigenous innovation only depends on one single firm，by contrast，firms have to follow the trend of open innovation. However，how do deal with the “innovation paradox” between openness and independence becomes the critical problem of building the domestic “core”. This case takesHiSilicon’s indigenous innovation in the era of open innovation as an example，which truly reviews the whole process of HiSilicon’s indigenous innovation from following，catch-up and leading in IC industry. This case provide a meaningful exploration of firm’s indigenous innovation in the era of open innovation for researchers，students and practitioners to understand and master the theoretical content such as innovation strategy，indigenous innovation process，the connotation of “open based on indigenous” and “indigenous under open environment”，the open innovation paradox. It also generates insights for Chinese firms to transit from closed indigenous innovation to indigenous-based open，collaborative and holistic innovation，for China to speed up the breakthrough of key technologies and go beyond catch-up，so as to achieve high-value manufacturing and high-quality development.