Innovation is the first power that leads to long-term development. Today the global innovation is accelerating，co-innovation is a new paradigm that goes beyond the collaborative innovation，science-based innovation is becoming new peak of global competition，holistic innovation is becoming the new innovation paradigm with Chinese characteristics and speaks to global frontiers. However，while China has made remarkable breakthroughs in the past decades，there are still new challenges ahead，which call for China’s strategic transition from innovation driven development to innovation leading development. Enter the new development stage，the key to innovation development is taking the innovation leading development as the main innovation strategy，and building the new type of national innovation system to strengthen the national strategic technology power，at the same time to nourish technology innovation as well as holistic innovation，so as to achieve high-level technology self-reliance and self-improvement，generating strong support for new development.