COVID-19 epidemic had huge impact on the economic society at the beginning of 2020. This report analyzes the impact of the COVID-19 epidemic on Guangdong provincial economy and the labor market through field interviews，questionnaire survey and comprehensive research. Various human resources and social security policies and measures in response to Covid-19 epidemic in Guangdong were reviewed and evaluated. On this basis，it summarized the main highlights of human resources and social security policies to deal with the COVID-19 epidemic in Guangdong：Fast，more measures，technology，service. So as to put forward the response measures on human resources and social security in the gradual transition from the normal epidemic to the post-epidemic era：building a multi-level social security system，taking different policies and measures according to the different economic areas，transforming and upgrading social security services，refining the standards and subsidies for enterprises，solving problems of employment through working together at various levels，in various regions and in various forms，establishing an emergency management system for major public incidents，strengthening research on human resources and social security policies for new forms of employment and flexible employment.