Innovation and entrepreneurship demo center is an important starting point for the effective landing of national innovation and entrepreneurship work，an important carrier to enhance the ability of innovation and entrepreneurship and improve the employability，and plays an important leading role in promoting reform，stabilizing employment and strengthening momentum. Based on the systematic analysis of the general situation of Henan innovation and entrepreneurship demo centers in recent years，and the effectiveness and existing problems of entrepreneurship-driven employment，this paper puts forward an effective way to enhance the employment capacity of Henan innovation and entrepreneurship demo centers，from the aspects of strengthening of entrepreneurship policy protection，strengthening the support of entrepreneurship and innovation talent elements，strengthening financial support capacity，creating a good development environment，etc. This paper provides guidelines and reference for the establishment of high-level innovation and entrepreneurship demo centers.