Activating the vitality of innovation factors and improving the efficiency of innovation diffusion are the keys to China’s transformation from traditional factor-driven to innovation-driven under the background of anti-globalization and technological protection in developed countries. This report uses corporate big data analysis and spatial regression analysis to measure the effectiveness of innovation diffusion in Beijing-Tianjin-Hebei. The study found that the unbalanced spatial distribution of innovation resources in Beijing-Tianjin-Hebei is relatively significant，and the innovation vitality of universities has not been effectively stimulated. The promotion effect of regional innovation output is relatively limited. The innovation results of the innovation source （Beijing） mainly flow outside Tianjin and Hebei，and the innovation undertaking （Tianjin） technology intermediary and intellectual property protection entities are underdeveloped；in 2014，the Beijing-Tianjin wing coordinated development After the strategy was put forward，the role of basic R&D investment in promoting economic growth has not changed significantly，and the role of absorption and transformation of input and the output of innovation results in promoting economic growth has undergone significant changes.