Since the 18th National Congress of the Communist Party of China，the campaign against corruption in state-owned enterprises has been largely successful. However，in the process of advancing the anti-corruption work，due to joint supervision，rigid systems and economic incentives as well as corruption prevention，internal control and governance，anti-corruption difficulties caused by inherent systems and mechanisms of state-owned enterprises，such as obstructions to supervision at the same level，limited means of supervision，lagging system construction and inadequate incentive mechanisms，are thoroughly exposed. Regarding how to enhance the construction of state-owned enterprises’ anti-corruption governance systems in the new era，based on the practice of the province-administered enterprises in Guangdong on the anti-corruption governance，“six organic combinations” are presented herein，including organic combinations of political supervision and economic supervision，principal supervision and specific supervision，discipline supervision and all-staff supervision，corruption prevention and system construction，internal supervision and external supervision，supervision discipline execution and corporate governance，so as to give full play to the supervisory role of state-owned enterprises in all elements to advance the construction of effective anti-corruption scientific governance systems in state-owned enterprises.