The outbreak and spread of COVID-19 has caused extremely unfavorable harm to the global economy. International trade bears the brunt of impact，breaking the normal pattern of international division of labor and industrial chains. Under this impact，the G20 are facing greater difficulties and challenges about international trade cooperation in the post-pandemic era. The anti-globalization，internal organization differentiation，reconstruction of trade rules，and Sino-US economic and trade disputes are not conducive to the order development of G20 international trade. To this end，the G20 should reach a concerted effort in reducing trade costs，developing service trade，and promoting trade financing. China should persist in opening up，establish broader economic and trade cooperation with the other countries，and promote high-quality trade development.