Based on the data of the Provincial Situation Survey（2020）of the Guangdong Academy of Social Sciences，this paper analyzes and studies the basic situation of urban and rural families in Guangdong Province according to the data of the household survey since 2018. In particular，the changes of family economy，family model，population structure，social mentality and lifestyle in Guangdong were analyzed in the post-epidemic era. The study shows that the work and life style of Guangdong families has changed greatly under the influence of the new corona-virus pneumonia epidemic，and online education and telecommuting are popularized rapidly. The new life style based on keeping social distance has a certain degree of impact on Guangdong families，and has a different degree of impact on family economic life，employment situation，social mentality and so on. At the same time，the work of epidemic prevention and control has been carried out in an orderly and effective manner，which makes Guangdong families have higher trust in the Party and the government than in previous years，and the evaluation of satisfaction with the work of the Party and the government has always maintained a high level.