Currently，the regional competition under the trend of open innovation is becoming increasingly fierce，and the policy demands of various innovation entities in the fields of talents，taxation，and intellectual property protection are constantly undergoing new changes. Zhongguancun Science City，as one of the regions with the most significant advantages of institutional innovation，urgently needs to carry out a new round of pilot policy explorations and take the lead in making breakthroughs，in order to maintain the advantage of the scientific and technological innovation experimental field. This paper sorts out the breakthrough policies involved in the “two districts” plan of Beijing，and at the same time，combines the demands of various innovation entities，puts forward four suggestions on pilot policy that need to be implemented as soon as possible，including tax policies，land use policies，digital economy policies，intellectual property protection policies.