The COVID-19 epidemic has caused a great impact on economic and social development in the Changjiang Middle Reaches Megalopolis，especially the economic and social development of Hubei province was almost at a standstill. Under the leadership of the CPC Central Committee and the State Council，the three provinces have helped each other and achieved decisive results in fighting against COVID-19. At the same time，the three provinces have issued a series of special measures and regulations to speed up economic recovery around the industrial chain. At present，the major economic indicators of the Changjiang Middle Reaches Megalopolis have recovered month-on-month，and the prospect of economic and social recovery has been fully opened up. In the future，the Changjiang Middle Reaches Megalopolis will further enhance the level and level of cooperation in green coordinated development，world-class industrial clusters，strong markets in Central China，and the construction of innovation highlands and so on，strive to elevate the interconnected development of the Changjiang Middle Reaches Megalopolis to the national strategy.