The New industrial city has made some achievements inmotivating the economic development of small and medium-sized cities，and has also made great contributions to promoting the characteristic development of manufacturing industry in small and medium-sized cities. On this basis，this paper summarizes the development types of manufacturing industry in small and medium-sized cities，then puts forward the realization path and specific measures for the new industrial city to promote the characteristic development of manufacturing industry in small and medium-sized cities，including location advantage，resource advantage，culture advantage and ecological endowment advantage. Finally，from the government，industry associations and professional institutions，this paper expounds the protection mechanism of promoting the characteristic development of manufacturing industry in small and medium-sized cities by new industrial city.