the COVID-19 epidemic is a major public health emergency，and the fight against the epidemic is a comprehensive test of the national governance system and governance capacity. Jiangsu Province has made remarkable achievements in the prevention and control of public health emergencies by timely initiating response to public health emergencies，building an epidemic defense line for early detection of cases，and paying close attention to the management of epidemic prevention and control. In the process of response，there are also problems in the major epidemic prevention and control system and mechanism：first，the early warning and evaluation of public health emergencies are not timely and accurate；second，the core competence of CDC in emergency management needs to be improved；third，the imperfect public health anti epidemic system affects the “wartime” prevention and control function；fourth，it is urgent to strengthen the system construction of health events；fifth，the response mechanism and coordination mechanism under abnormal conditions are not perfect. In view of the above problems，the suggestions are as follows：first，to establish the concept and guidance of “big public health”；second，to build a new public health safety prevention and control network；third，to improve the operational efficiency of public health emergency system；fourth，to strengthen the core capacity construction of disease control institutions.