Hexi corridor is not only a fertile location for Gansu’s development，but also an important ecological security barrier in the west，bearing the “One Belt And One Road” construction and the important task of opening Gansu to the west. Water resource shortages are the main factor restricting current and future sustainable corridor development，and so successful water management and protecting the Qilian Mountains are key. To realize Hexi Corridor sustainable development，the focus should be on compiling a regional development plan，which includes efficient utilization of water resources，ecological industrial system construction，implementing three protections（Qilian Mountain，oasis ecological environment，historical and cultural），building four economic zones（Jinwu，Zhangye，Jiujia，Dunhuang），and implementing green development.