Through the construction of the science and technology（S&T）innovation driving force index evaluation system for the cities in Yangtze River Delta，and based on the AHP-EVM model to set the weight of the subjective-objective comprehensive indicators，this paper gets the S&T innovation driving force composite index，including four special indices of the S&T innovation input，the S&T innovation carrier，the S&T innovation output，the S&T innovation performance，as well as 10 secondary indicators score，and focuses on the analysis of the top 10 cities driven by the S&T innovation in the Yangtze River Delta. The results show that compared with last year’s results，the performance of Jiangsu and Zhejiang cities declined overall，while shanghai improved，and some of Anhui’s leading cities，driven by economic development，improved the driving force of the S&T innovation.