In order to promote the construction of Luoyang sub central city and create regional development growth pole，we should give full play to the leading role of innovation，and take innovation as the core force of high-quality development power transformation in Luoyang. This paper summarizes the practice and achievements of Luoyang in innovation and development，and points out that there are still some deficiencies in cultivating various innovation subjects，activating technology trading market，gathering high-end talents，and creating a good innovation ecology. Therefore，we should focus on the construction of Luoyang area of zhengluoxin National Independent Innovation Demonstration Zone，enhance the ability of independent innovation，integration innovation，integration and innovation We should open up innovation capability，optimize regional innovation and entrepreneurship ecology，and promote comprehensive innovation with scientific and technological innovation.