As the forefront of China’s reform and opening up，Pudong New Area is the core functional area for Shanghai to build a science and technology innovation center with global influence. After years of development，Pudong New Area has built a scientific and technological innovation system with regional characteristics from the aspects of innovation resources gathering，innovation subject cultivation，and innovation atmosphere building. The core framework of the scientific and technological innovation center has been basically formed，but it still has many deficiencies. Next，Pudong New Area should strengthen the systematic integration of science and technology innovation policies，enhance the overall level of the superior high-tech industry chain，guide the collaborative linkage of various innovation subjects，build a professional scientific and technological innovation support system，so as to promote Shanghai to build a science and technology innovation center with global influence as soon as possible.