At the present stage，China is speeding up to form a new development pattern that takes the domestic market as the mainstay and allows the domestic and foreign markets to boost each other. The integration of the Yangtze River Delta （YRD）plays a key role in accelerating the establishment of a new development pattern in China. In this process，Pudong New Area should actively take advantage of its location and institutional highlands to further development and opening-up the area，exert an agglomeration and radiation effect，continuously advance scientific and technological innovation，raise the industrial and technological level of the YRD region，promote the division of labor and collaboration of economic production in different regions，and promote the integration of the YRD region. As an economic leader in the YRD region，the further development and opening-up of Pudong New Area promotes the rationalization and optimization of the industrial structure in the YRD region，optimizes the allocation of regional resources，improves regional production efficiency，enhances the capacity of the YRD urban agglomeration，and accelerates the formation of a new development pattern. Under the new era and the formation of a new development pattern，Pudong makes efforts to be a pioneering leader of technological and industrial innovation in China，accelerating the creation of a new highland of reform and opening-up，powerfully driving the economic and social development of the YRD region，and promoting the sustainable economic development in China.